6 The birthplace of Blessed Ephrem could have been Nisibi or Edessa. What is certain is that he was connected by blood with the martyrs of the last persecution. His parents brought him up as a Christian. If they did not have the comforts of a wealthy life, they had the far greater and more splendid distinction that "they had professed Christ in judgment." In his youth Ephrem, as he bewails in his little book of confessions, was languid and remiss in resisting the temptations by which that age is usually troubled. He was hot tempered, easily angered, quarrelsome, and unrestrained in mind and language. But while in prison on a false charge, he began to despise human things and the empty joys of this world. Therefore, as soon as he was exonerated, Ephrem at once put on the habit of a monk and ever after devoted himself completely to the exercises of piety and to the study of the Sacred Scriptures. James, the bishop of Nisibi, one of the three hundred eighteen Fathers of the Nicene Council, who had established a renowned school of exegesis in the episcopal city, became his patron. He not only fulfilled James' expectations with his diligent and sharp-witted commentaries on the Bible, but even surpassed them. As a result, he soon became the greatest of all commentators of that school, earning the title Doctor of the Syrians. Soon he had to interrupt his study of Sacred Literature because Persian troops threatened the city. He urged on the citizens in their vigorous resistance to the Persians. With the aid of the prayers of James the bishop, they were defeated; however, after his death, the Persians again besieged the city. This time, in 363, it did fall. Because Ephrem preferred exile to serving infidels, he migrated to Edessa. There he diligently exercised the duties of an ecclesiastical doctor.
Source: Principi Apostolorum Petro (Vatican.va)