22 The first missionary sent deserted the held of battle, either because he despaired of converting these heretics or because he feared them. But St. Francis de Sales who, as We have pointed out, had already offered himself for missionary work to the Bishop of Geneva, started on foot in September, 1594, without food or money, and accompanied by no one except a cousin of his, to take up this work. It was only after long and repeated fasts and prayers to God, by Whose aid alone he expected his mission to be successful, that he attempted to enter the country of the heretics. They, however, would not listen to his sermons. He sought then to refute their erroneous doctrines by means of loose leaflets which he wrote in the intervals between his sermons. These leaflets were distributed about in great quantities and passed from hand to hand with the object of having them find their way into the possession of the heretics.
Source: Rerum Omnium Perturbationem (Vatican.va)