Texts Explained; Sixthly, Proverbs 8:22, Continued. Our Lord not said in Scripture to be 'created,' or the works to be 'begotten.' 'In the beginning' means in the case of the works 'from the beginning.' Scripture passages explained. We are made by God first, begotten next; creatures by nature, sons by grace. Christ begotten first, made or created afterwards. Sense of 'First-born of the dead;' of 'First-born among many brethren;' of 'First-born of all creation,' contrasted with 'Only-begotten.' Further interpretation of 'beginning of ways,' and 'for the works.' Why a creature could not redeem; why redemption was necessary at all. Texts which contrast the Word and the works
72 But if the Word were a work, then certainly He as others had been made in Wisdom; nor would Scripture distinguish Him from the works, nor while it named them works, preach Him as Word and own Wisdom of God. But, as it is, distinguishing Him from the works, He shows that Wisdom is Framer of the works, and not a work. This distinction Paul also observes, writing to the Hebrews, 'The Word of God is quick and powerful, and sharper than any two-edged sword, reaching even to the dividing of soul and spirit, joints and marrow, and a discerner of the thoughts and intents of the heart, neither is there any creature hidden before Him, but all things are naked and open unto the eyes of Him with whom is our account.'
For behold he calls things originate 'creature;' but the Son he recognises as the Word of God, as if He were other than the creatures. And again saying, 'All things are naked and open to the eyes of Him with whom is our account,' he signifies that He is other than all of them. For hence it is that He judges, but each of all things originate is bound to give account to Him. And so also, when the whole creation is groaning together with us in order to be set free from the bondage of corruption, the Son is thereby shown to be other than the creatures.
For if He were creature, He too would be one of those who groan, and would need one who should bring adoption and deliverance to Himself as well as others. But if the whole creation groans together, for the sake of freedom from the bondage of corruption, whereas the Son is not of those that groan nor of those who need freedom, but He it is who gives sonship and freedom to all, saying to the Jews of His time, 'The servant remains not in the house for ever, but the Son remains for ever; if then the Son shall make you free, you shall be free indeed;' it is clearer than the light from these considerations also, that the Word of God is not a creature but true Son, and by nature genuine, of the Father.
Concerning then 'The Lord has created me a beginning of the ways,' this is sufficient, as I think, though in few words, to afford matter to the learned to frame more ample refutations of the Arian heresy.
Source: Four Discourses Against the Arians (New Advent)