8 Now then, if it seem good, brethren, those men being repulsed, and ever wandering in their own blindness, unless in humility they be healed, let us inquire why our Lord answered His mother in such a manner. He was in an extraordinary manner begotten of the Father without a mother, born of a mother without a father; without a mother He was God, without a father He was man; without a mother before all time, without a father in the end of times. What He said was said in answer to His mother, for “the mother of Jesus was there,” and “His mother said unto Him.”
All this the Gospel says. It is there we learn that “the mother of Jesus was there,” just where we learn that He said unto her, “Woman, what have I to do with you? Mine hour is not yet come.” Let us believe the whole; and what we do not yet understand, let us search out. And first take care, lest perhaps, as the Manichæans found occasion for their falsehood, because the Lord said, “Woman, what have I to do with you?” the astrologers in like manner may find occasion for their deception, in that He said, “Mine hour is not yet come.”
If it was in the sense of the astrologers He said this, we have committed a sacrilege in burning their books. But if we have acted rightly, as was done in the times of the apostles, it was not according to their notion that the Lord said, “Mine hour is not yet come.” For, say those vain-talkers and deceived seducers, you see that Christ was under fate, as He says, “Mine hour is not yet come.” To whom then must we make answer first— to the heretics or to the astrologers? For both come of the serpent, and desire to corrupt the Church's virginity of heart, which she holds in undefiled faith.
Let us first reply to those whom we proposed, to whom, indeed, we have already replied in great measure. But lest they should think that we have not what to say of the words which the Lord uttered in answer to His mother, we prepare you further against them; for I suppose what has already been said is sufficient for their refutation.
Source: Tractates on the Gospel of John (New Advent)