What is the reason that at this point he speaks in the tone of invective (καταφορικὥς)? Great was his boldness of speech, when at the point to die: for in fact I think he knew that this was the case. “You stiffnecked,” he says, “and uncircumcised in heart and ears.” This also is from the prophets: nothing is of himself. “You do always resist the Holy Ghost: as your fathers did, so do ye.” When it was not His will that sacrifices should be, you sacrifice: when it is His will, then again ye do not sacrifice: when He would not give you commandments, you drew them to you: when you got them, you neglected them.
Again, when the Temple stood, you worshipped idols: when it is His will to be worshipped without a Temple, you do the opposite. Observe, he says not, “You resist God,” but, “the Spirit:” so far was he from knowing any difference between Them. And, what is greater: “As your fathers did,” he says, “so do ye.” Thus also did Christ (reproach them), forasmuch as they were always boasting much of their fathers. “Which of the prophets have not your fathers persecuted? And they have slain them which showed before of the coming of the Just One:” he still says, “the Just One,” wishing to check them: “of Whom you have been now the betrayers and murderers”— two charges he lays against them — “who have received the Law by the disposition of Angels, and have not kept it.” How, “By the disposition of Angels?”
Some say (The Law), disposed by Angels; or, put into his hand by the Angel Who appeared to him in the bush; for was He man? No wonder that He who wrought those works, should also have wrought these. “You slew them who preached of Him,” much more Himself. He shows them disobedient both to God, and to Angels, and the Prophets, and the Spirit, and to all: as also Scripture says elsewhere: “Lord, they have slain Your Prophets, and thrown down Your altars.” They, then, stand up for the Law, and say, “He blasphemes against Moses:” he shows, therefore, that it is they who blaspheme, and that (their blasphemy is not only against Moses, but) against God; shows that “they” from the very beginning have been doing this: that “they” have themselves destroyed their “customs,” that there is no need of these: that while accusing him, and saying that he opposed Moses, they themselves were opposing the Spirit: and not merely opposing, but with murder added to it: and that they had their enmity all along from the very beginning.
Do you see, that he shows them to be acting in opposition both to Moses and to all others, and not keeping the Law? And yet Moses had said, A Prophet shall the Lord raise up unto you: and the rest also told of this (Christ) that He would come: and the prophet again said, “What house will you build Me?” and again, “Did ye offer to Me slain beasts and sacrifices” those “forty years?”
Source: Homilies on Acts (New Advent)