“And so spoke, that a great multitude,” etc. Do you mark the nature of the Gospel, the great virtue it has? “Made their minds evil-affected,” it says, “against the brethren:” i.e. slandered the Apostles, raised numberless accusations against them: (these people, being simple, they “made evil-affected,” disposed them to act a malignant part. And see how on all occasions he refers all to God. “Long time,” he says, “abode they speaking boldly in the Lord, which gave testimony unto the word of His grace.” Think not this (expression, “Gave testimony,”) has anything derogatory (to the Lord's Divine Majesty): “Who witnessed,” it is said, “before Pontius Pilate.” Then the boldness— “and granted signs and wonders to be done by their hands.”
Here he speaks it as concerning their own nation. “And the multitude of the city,” etc. (<!--<span class="stiki"></span>-->v. 4, 5.) Accordingly they did not wait for it, but saw the intention of attacking them, and fled, on no occasion kindling their wrath, “to the cities of Lycaonia, Lystra, and Derbe, and the adjacent region.” They went away into the country, not into the cities only.— Observe both the simplicity of the Gentiles, and the malignity of the Jews. By their actions they showed that they were worthy to hear: they so honored them from the miracles only.
The one sort honored them as gods, the other persecuted them as pestilent fellows: and (those) not only did not take offense at the preaching, but what say they? “The gods, in the likeness of men, have come down to us;” but the Jews were offended. “And they called Barnabas, Jupiter; and Paul, Mercurius.” (<!--<span class="stiki"></span>-->v. 11, 12.) I suppose Barnabas was a man of dignified appearance also. Here was a new sort of trial, from immoderate zeal, and no small one: but hence also is shown the virtue of the Apostles, (and) how on all occasions they ascribe all to God.
Source: Homilies on Acts (New Advent)